Sulfatides are a class of sulfated galactosylceramides synthesized primarily in the oligodendrocytes in the central nervous system. Sulfatides are a type of sulfolipid. Sulfatides are thought to play a major role in myelin function and stability, as evidenced by the fact that mice lacking the enzyme necessary to produce sulfatides during myelin sheath formation have thinner myelin sheaths, and experience progressive hindlimb paralysis as a result of demyelination of their lower spinal cords.
Sulfatidosis, or metachromatic leukodystrophy, is a lysosomal storage disease characterized by accumulation of sulfatides due to an inability to degrade them in lysosomes.
Alterations in sulfatide metabolism, trafficking, and homeostasis are present in the earliest clinically recognizable stages of Alzheimer's disease.
Several studies have demonstrated a relationship between vitamin K and sufatides. After mice were administered warfarin to decreased their brain sulfatide levels, vitamin K administration was able to restore these levels to normal.
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